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What Is the Endocannabinoid System and What Does it Have to Do With Medical Marijuana?

At PA Medical Marijuana Doctor, we don’t just provide help with the process for applying for a medical marijuana card in Philadelphia PA. We’re also the source for information and new regarding medical marijuana. The endocannabinoid system (ECS) is a biological system in the body that balances and regulates certain functions. This complex cell-signaling system was discovered in the early 1990s by scientists trying to figure out how cannabis affects the body. And when it comes to the ECS, research is ongoing; however, it has been proven to play a role in regulating functions such as memory, mood, sleep, appetite, reproduction, and fertility. Whether or not you use cannabis, the ECS still exists and is active within your body.

How Does the Endocannabinoid System Work?

The ECS is composed of a network of cannabinoid receptors. The most active of these receptors are cannabinoid receptor type 1 (CB1), and cannabinoid receptor type 2 (CB2). The ECS uses its own enzymes and endocannabinoids. These work together to maintain homeostasis in the functions mentioned above.

If something happens to disturb our natural homeostasis (balance), the body releases endocannabinoids, and they bind to our CB1 or CB2 receptors. Once the endocannabinoids bind to these receptors, automatic bodily responses are triggered, helping to restore balance to our essential functions.

One of the primary responses in the body that the ECS regulates is the response to stress. When stress occurs inside the body, the ECS can work to reduce the effects of this stress and create calm throughout the body.

How Does Medical Marijuana Affect the ECS?

Compounds present in cannabis include CBD, THC, and other phytocannabinoids and terpenoids. These compounds help the ECS to maintain homeostasis by binding to our CB1 and CB2 receptors in the same way that our natural endocannabinoids do. Therefore, they can enhance or influence the function of the endocannabinoid system.

How do the Cannabinoids Present in Medical Marijuana Work With the Endocannabinoid System?

As scientific research reveals more about the ECS, scientists are exploring the roles that THC, CBD, and CBN could play in supporting the system. Science has identified a strong relationship between the ECS and CBD. Cannabinoids found in CBD isolates, oils, and tinctures interact with our body’s cannabinoid receptors, stimulating various physiological responses.

THC, which can be found in medical marijuana, is considered an agonist of both CB1 and CB2 receptors. This compound binds directly to these receptors and stimulates a strong physiological reaction

The use of medical marijuana helps people to boost their natural endocannabinoid system by stimulating responses in the receptors located throughout our bodies.  This can help to restore equilibrium to some of the critical functions associated with good health.

For more information regarding medical marijuana and its uses, or for help with the process for applying for a MMJ card in Philadelphia, PA, contact us today.


Dr. McCoy treated me with great compassion and took the time to listen to my needs. I really felt like he cared about helping me.

- Tyler

My son suggested I try using medical marijuana for my back pain. I made an appointment with Dr. McCoy, got my MMJ card, and my back has never felt better!

- Suzanne

I was skeptical of medical marijuana at first, but Dr. McCoy took the time to educate me and made the entire process of getting my MMJ card simple and straightforward.

- Jason

Step 1: Get Registered

Create a profile in the PA state Medical Marijuana Registry. This includes basic personal data like your name, current address, and contact information. You must have a Pennsylvania driver’s license or state ID card. 

Step 2: Get Certified

Schedule a consultation with PA Medical Marijuana Doctor to meet with a PA state-approved physician who can certify that you suffer from one of the qualifying medical conditions to participate in PA’s medical marijuana program.

Step 3: Get Your Patient ID

Once you’re certified by an approved physician, return to the Medical Marijuana Registry and finish filling out your application for a medical marijuana ID card. Once you receive your card, you can purchase medical marijuana from a dispensary.